Aggregatore di feed

Forthcoming Issues

Immunology Laboratory Testing

Contributors

MILENKO JOVAN TANASIJEVIC, MD, MBA

Our Pathogens Are Not Standing Still and Neither Can We

In 1 or 2 generations, we have gone from a world in which there were no cures for most infections to a declaration that the war against infectious disease was won. That period of ephemeral confidence was followed by the inexorable march toward increasingly resistant pathogens that quickly learned to evade each new advance and our own race, sometimes successful, sometimes faltering, to produce new antimicrobials and vaccines.

Predicting Bacterial Versus Viral Infection, or None of the Above

Sepsis and pneumonia cause significant morbidity and mortality worldwide. Despite improvements in diagnostic methodologies for organism identification, the early recognition and further risk stratification of these infections can be challenging. Although traditional clinical scoring systems are beneficial for the management of sepsis and pneumonia, biomarkers supporting the diagnosis and management of these infectious diseases are needed. Many biomarkers have been identified and there is no lack of studies and meta-analyses assessing the utility of biomarkers. Focusing primarily on sepsis and pneumonia, this article discusses the most commonly used biomarkers for which clinical laboratory testing methods are available.

Direct-from-Specimen Pathogen Identification

This article describes the current state of the art with regards to commercially available syndromic panels for blood stream infections, gastrointestinal pathogen detection, respiratory tract infections, and central nervous system infections, while providing a provocative and speculative look into the future of syndromic panel testing for infectious diseases.

Distributed Microbiology Testing

We discuss the current practice of point-of-care diagnostics in infectious diseases as methods transition from antigen-based to molecular, and beyond simple molecular to the next generations of point-of-care testing methods. We evaluate the role of point-of-care at different sites of care and describe and evaluate trends likely to be driven by advances in molecular methodology, emerging biomarkers, and informatics. We describe strengths, weaknesses, opportunities, and threats to the development of point-of-care diagnostics in the near (1–10 years) and more distant (10–20 years) future.

Next-Generation Sequencing in Clinical Microbiology

Next-generation sequencing (NGS) applications have been transitioning from research tools to diagnostic methods and are becoming more commonplace in clinical microbiology laboratories. These applications include (1) whole-genome sequencing, (2) targeted next-generation sequencing methods, and (3) metagenomic next-generation sequencing. The introduction of these methods into the clinical microbiology laboratory has led to the theoretic question of “Will NGS-based methods supplant traditional methods for strain typing, identification, and antimicrobial susceptibility prediction?” The authors address this question and discuss where we are at now with clinical NGS applications for infectious diseases, what does the future hold, and at what cost?

Total Laboratory Automation

The first clinical microbiology laboratory in the United States adopted total automation for bacteriology processing in 2014. Since then, others have followed with installation of either the BD Kiestra TLA or the Copan WASPLab. This article discusses commercially available automated systems in the United States; why automation is needed; and quality improvements, efficiency, and cost savings associated with automation. After learning how these systems are used, gains and losses experienced, and how one can afford the most expensive equipment ever purchased for clinical microbiology laboratories, the question is, how can one afford not to purchase one of these microbiology automation systems?

DIETISTA,FISIOTERAPISTA,P SICOLOGO,TECNICI DI LABORATORIO(LAVORATORI OSPEDALIERI)

OSPEDALE DI MAIDSTONE - Roma - , TECNOLOGO DI LABORATORIO MEDICO dietista FISIOTERAPISTA PSICOLOGO Metodo di applicazione...) TECHS (RADIOLOGY TECH, ULTRASOUND TECH, SURGICAL TECH) TECNICI DI LABORATORIO TERAPISTA...
Categorie: Offerte di lavoro

Do You Care About Hospital Rankings?

Pathology & Lab Medicine - Medscape - Sab, 31/08/2019 - 03:23
Researchers have critiqued the methodologies of popular hospital rankings as "likely to misclassify hospital performance."
Medscape Reader Polls

First Results for Nanosphere Focal Therapy in Prostate Cancer

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
In a new focal ablation technology for prostate cancer, gold silica nanoshells at the tumor vasculature can be triggered by near-infrared light from lasers to cause photothermal ablation.
Medscape Medical News

HCC and DAA Treatment in Decompensated Cirrhosis

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
This review explores controversies surrounding the potential impact of DAA therapy on the incidence and prognosis of hepatocellular carcinoma in patients with advanced liver disease.
Alimentary Pharmacology & Therapeutics

Sarcoid-Like Ustekinumab Induced Granulomatous Reaction

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
This patient presented with a rare disseminated sarcoid-like reaction while undergoing treatment with the monoclonal antibody ustekinumab for refractory psoriasis.
Journal of Medical Case Reports

Does the US Unnecessarily Discard Donor Kidneys?

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
According to a recent study, many of the deceased-donor kidneys discarded in the United States would be safely transplanted in France.
Medscape Medical News

Can Minimum Volume Thresholds Assure Complex Cancer Surgery Quality?

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
Setting volume thresholds does not guarantee that hospitals will adhere to those standards or that patients will have access to hospitals that do, a study of high-risk cancer surgery patients reveals.
Reuters Health Information

MPV, PDW, and PLT Count in ITP and Essential Thrombocytopenia

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
This study analyzed and compared MPV and PDW values in immune thrombocytopenic purpura and essential thrombocythemia. How do they compare with values in healthy individuals?
Laboratory Medicine

Genetic Testing in the Diagnosis, Biology of Acute Leukemia

Pathology & Lab Medicine - Medscape - Ven, 30/08/2019 - 02:23
This workshop examined how molecular genetic findings can aid in the diagnosis of and elucidate the pathogenesis of acute leukemias.
American Journal of Clinical Pathology
Condividi contenuti