Novità nel mondo di Medicina di Laboratorio

Proteomic test identified patients with diabetes at high risk of kidney disease before they had detectable microalbuminuria. However, spironolactone did not mitigate the risk.
Medscape Medical News

The recent surge of lung injuries among users of e-cigarette products appears to be caused by chemical toxicity and not from the accumulation of lipids in the lungs, researchers say.
Medscape Medical News

Abbott's Architect Stat troponin-I assay can identify myocardial infarction several hours sooner than standard troponin tests and improve diagnosis in women, the company says.
FDA Approvals

Children of women exposed to endocrine disruptors during pregnancy can suffer respiratory effects years later, adding to existing concerns about health risks related to bisphenol A (BPA).
Medscape Medical News

Yips, a focal task-specific dystonia, may be more prevalent among golfers than has previously been thought, a Dutch study has found. It affects athletes in other sports and activities as well.
Medscape Medical News

"We use the newer A1c variability score, and [we] followed a lifetime trajectory from new diagnosis [of type 2 diabetes] to the [adverse] event," says the senior author in explaining the research.
Medscape Medical News

This case report brings attention to the potential of eye involvement in dengue viral infection.
Journal of Medical Case Reports

This study indicates that the histological severity of NAFLD is strongly associated with advanced colorectal neoplasm.
Liver International

These 5 steps will help clinicians determine whether patients with a pathogenic variant in a cancer susceptibility gene should be referred for germline testing.
Journal of Oncology Practice

Using an experimental assay to analyze just a few drops of blood appears to be predictive of vascular complications in diabetes; validation studies are next and a clinical trial is planned.
Medscape Medical News

In a RE-VERSE AD subgroup analysis, idarucizumab reversed the effects of dabigatran in more than 98% of patients, regardless of renal function.
Medscape Medical News

The final survival data from FLAURA establishes osimertinib as front-line therapy for patients with EGFR-mutated NSCLC. Give the best therapy first, experts say.
Medscape Medical News

Results from CheckMate 227 suggest that combination nivolumab and ipilimumab may eliminate the need for chemotherapy in advanced NSCLC, regardless of PD-L1 status.
Medscape Medical News

With the combination of ipilimumab and nivolumab, 50% of patients are still alive after 5 years, a survival rate remarkably higher than that seen with either agent alone.
Medscape Medical News

U.S. federal agents raided genetic testing laboratories, and 35 people were criminally charged in four states in a crackdown on genetic testing fraud that officials said on Friday caused $2.1 billion in losses to federal healthcare insurance programs.
Reuters Health Information

Three medical stories that we didn't cover, explained.
Medscape

Apotex Corp has voluntarily recalled all pack sizes and formats of ranitidine tablets in the US on a 'precautionary basis' after a probable carcinogen was found in other generic Zantac products.
News Alerts

Immune-targeted therapeutics are being used in cancer. Immune “checkpoint inhibition” provides promise for prolonged disease-free patient survival. Use of immune checkpoint inhibitors in cancer has coincided with the onset of immune-related adverse events (irAEs). irAEs are caused by a break in host self-tolerance, which can be deadly. Acute management of irAEs is complicated by difficulty making a prompt clinical diagnosis. The goal is to maximize anticancer benefit while minimizing irAE risk. We currently lack diagnostic tools to assess pretreatment irAE risk and facilitate diagnosis. Current immunologic understanding of irAEs is discussed with an emphasis on how patients with congenital syndromes of T-cell activation may inform this understanding. The prospects of improving diagnostics for and treatment of irAEs are discussed.

Antiphospholipid syndrome (APS) is as an autoimmune disease characterized by thrombosis and/or specific pregnancy-related morbidity associated with persistent antiphospholipid antibodies, namely, lupus anticoagulant and IgG and IgM antibodies to cardiolipin and beta2 glycoprotein I. Optimal antibody detection plays a central role in diagnosis and classification. This review discusses antiphospholipid antibodies helpful for diagnosing APS. It includes the criteria and noncriteria antiphospholipid antibodies, methods for their detection, and challenges for clinical reporting and interpretation. The significance of using specific noncriteria antiphospholipid tests in an integrated diagnostic approach with criteria antiphospholipid makers for the diagnosis and management of APS is also reviewed.

The presence of antinuclear antibodies (ANAs), which include autoantibodies to extractable nuclear antigens (ENAs), in the sera of patients with connective tissue diseases provides useful immunologic and pathophysiologic insight into the nature of their disease. This article discusses the most commonly used diagnostic modalities for detecting and quantitating the presence of ANA: indirect immunofluorescence assay, enzyme-linked immunosorbent assay, and multiplex bead technology, which serve as useful screening tests. We also review testing for autoantibodies to ENAs, which are often helpful to confirm the diagnosis of a specific connective tissue disease.